The latest who classification of odontogenic tumors was published in pathology and genetics. The primary outcome variables were the incidence of. Hematopoieticreticuloendothelial eosinophilic granuloma handschuller christian. Study 54 odontogenic tumors flashcards from leah k. Tooth andor its supporting structures are often source of pain.
Odontogenic and nonodontogenic oral tumours in non. Odontogenic and nonodontogenic developmental cysts. Jan 29, 2020 adenomatoid odontogenic tumors pdf posted on january 29, 2020 by admin adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly. Nonodontogenic oral and maxillofacial infections intechopen. The odontogenic keratocyst is a relatively common developmental odontogenic cyst that represents approximately 10% to 14% of all jaw cysts. The world health organization classification of odontogenic and. The primary predictor variable was the histopathologic diagnosis, grouped into odontogenic tumors ots, non ots, and odontogenic cysts. Odontogenic and nonodontogenic tumors of the jaws introduction odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. It is a benign hamartomatous, noninvasive lesion with slow but progressive growth. This retrospective study was planned to ascertain the relative frequency of odontogenic tumors ots in an indian population in the light of the latest world health organization who classification. Chapter 21 odontogenic and non odontogenic tumors of the jaws introduction. The classification and behavior of epithelial odontogenic tumors and cysts in human beings, dogs, and cats are discussed. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. Odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance.
It is defined by its characteristic microscopic features, which include basilar nuclear palisading and the production of keratin primarily in the form of parakeratin. Ameloblastoma, a type of odontogenic tumor involving ameloblasts. Materials and methods a retrospective study was performed on 19 biopsies of. The immunoprofile of odontogenic keratocyst keratocystic odontogenic tumor that includes expression of ptch, gli1 and bcl2 is similar to ameloblastoma but different from odontogenic cysts. Calcified substances form in many of these tumors and may be bone, cementum, amorphous and nonspecific calcifications, or a combination of these. At the time of writing 2016, it is still the most widely used classification system although a new revision is due to come up in 2017. Malignant tumors the radiographic appearance of odontogenic tumors varies, depending on their nature, location, and stage of development. Odontogenic cyst and non odontogenic cyst epithelium. The classification of odontogenic tumours was first formulated by pierre paul broca. Nonodontogenic tumors of the jaws oral surgery, oral medicine. Odontogenic keratocyst because of its behavior, many oral pathologists now consider the okc an odontogenic tumor that has a cystic form 2005 classi. The rare occurrence of tumors of the facial skeleton, whether of dental origin odontogenic or arising from bone osteogenic, makes it impossible for a single observer to appreciate fully the epi demiologic and clinical behavior of these lesions, even if he controls the case material of a large. In a survey of dogs with oropharyngeal tumors, scc was the second most frequently diagnosed oral tumor 24.
Often they may be complaining of pain from their teeth. Benign mixed epithelial and mesenchymal odontogenic tumours. In tumors in cats, fs represented the second most common oral tumor representing 12. Tumors arising within the jaws can be further subdivided into odontogenic and nonodontogenic. The dilemma the clinician faces is finding the correct origin of this pain whereby an effective treatment will provide relief. A central odontogenic fibroma cof is a rare and benign tumor accounting for only 0. The lesion appears both in the maxilla and mandible. The nomenclature of odontogenic and nonodontogenic cysts of the oral region is varied. Because odontogenic tumors arise from the tissues which make our teeth, they are unique to the jaws, and by extension almost unique to dentistry. Epidemiology most common odontogenic cyst is periapical. Update from the 4th edition of the world health organization. Most bone pathology can be seen in the gnathic and craniofacial bones. Pain of odontogenic and nonodontogenic origin springerlink. Tumor markers are molecules that help the pathologists for confirmatory diagnosis of histopathologically confounding lesions.
Our knowledge and understanding continues to evolve and it is clearly time for a more contemporary classification and discussion of odontogenic tumors. The four main stages considered are 1 dental lamina, 2 enamel organ, 3 reduced enamel epithelium, and 4 hertwigs epithelial root sheath. Overall, odontogenic tumors are rare and form only a small proportion of the lesions found in the jaw. It appears mostly in young patients and females, the maxillary. Non odontogenic pain pdf four 44 per cent of 100 nondental orofacial pain patients had previously. Many tumours other than those of the dental tissues appear from time to time in and around the mouth.
In 2005 the odontogenic fibroma was defined as a rare neoplasm characterized by varying amounts of inactivelooking odontogenic epithelium embedded in a mature, fibrous stroma and divided into an epithelium poor type, referred to as the simple type, and an epithelial rich type, often called the who type. Odontogenic tumors at university of colorado health. Clinical features of most benign odontogenic tumors are nonspecific. Nov 04, 2014 non odontogenic tumors of oral cavityi 1. Nonodontogenic oral and maxillofacial infections, a textbook of advanced oral and maxillofacial surgery, mohammad hosein kalantar motamedi, intechopen, doi. A survey of epithelial odontogenic tumors and cysts in. Radiographic features of cysts and benign tumors of the jaws steven r. Odontogenic tumors questions and study guide quizlet.
Multilocalcalcifying epithelial odontogenic tumor 17080 int j clin exp med 2016. The large majority of odontogenic tumors occur within the maxillofacial skeleton. While some authors have estimated its frequency of occurrence to be 1% 2, 3, others have reported. Clinical features of most benign odontogenic tumors are non specific. Although pain of dental origin is the most common orofacial pain, other non. The third most common tumor in dogs was fibrosarcoma representing 17. Pdf the world health organization classification of. In general, odontogenic tumors only occur in the jaws, but they have been reported in toothbearing tissues in such structures as dermoid cysts and teratomas. Learn vocabulary, terms, and more with flashcards, games, and other study tools. New entities which have been introduced include the sclerosing odontogenic.
In general, the more primitive the dental structures from which they are derived. Keratinocystic odontogenic tumor odontogenic keratocyst keratinocystic odontogenic tumor three important things associated with this diagnosis. Odontogenic tumors are relatively rare with estimated incidence of less than 0. Tooth andor its supporting structures are often source of. Nonodontogenic tumors of the facial bones in children and adolescents. With the reclassification of keratocystic odontogenic tumor in 2005 as an odontogenic tumor, there were 8129 odontogenic tumors reported with 3001 36. Pdf primary nonodontogenic tumors of the jawbones daphne. Who classification of odontogenic tumors, cysts and allied lesions. Mar, 2017 tumors arising within the jaws can be further subdivided into odontogenic and nonodontogenic. Petr schutz and hussein hassan hamed ibrahim june 26th 20. Odontogenic cyst and non odontogenic cyst free download as powerpoint presentation.
The 2005 who histological classification of odontogenic tumors lays out a classification system for neoplasms and other tumors related to the odontogenic apparatus. Unlabelled the practice of pathology is currently undergoing significant change, due to advances in the field of molecular pathology. Review article a rare case of multilocalcalcifying. This rare group of tumors may derive from the toothforming elements of the jaws. A survey of epithelial odontogenic tumors and cysts in dogs. A central odontogenic fibroma cof is a rare tumor of odontogenic origin with a diverse histopathology found in both the mandible and the maxilla. Based on published literature, odontogenic tumors are rare lesions with varying frequency. An odontogenic tumor is a neoplasm of the cells or tissues that initiate odontogenic processes examples include. Non odontogenic tumours of the jaw originating from bone and its mesenchymal tissue represent a large heterogeneous group of diverse diseases.
Nonodontogenic tumours of the jaw originating from bone and its mesenchymal tissue represent a large heterogeneous group of diverse diseases. Odontogenic and non odontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. Due to significant characteristics, they differ from bone tumours seen elsewhere in the skeleton. Odontogenic cyst and non odontogenic cyst epithelium anatomy. Introduction odontogenic tumors constitute a group of heterogeneous lesions derived from the tooth apparatus and odontogenic epithelial remnants. Who histological classification of tumours of the oral cavity and. Clinically seen on gingiva as a hard swelling, often between the teeth. The only nonodontogenic cyst included in the 2017 classification is. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. New tumour entities in the 4th edition of the world health. The distribution of jaw cysts according to diagnosis in a general population is. Correct diagnosis and treatment should include a careful assessment of clinical, radiological and histopathological. Odontogenesis, odontogenic cysts, and odontogenic tumors. Advances in assessing the volume of odontogenic cysts and.
Odontogenic tumor an overview sciencedirect topics. It may evolve from the dental follicle, the dental papilla, or the periodontal membrane. Odontogenic tumors are a heterogeneous group of lesions of diverse clinical behavior and histopathologic types, ranging from hamartomatous lesions to malignancy. Adenomatoid odontogenic tumor aot is a distinct odontogenic tumor that is exclusively odontogenic epithelium in origin which accounts for about 37% of all odontogenic tumors. First described by philipsen in 1956 as odontogenic keratocyst, it was renamed by the world health organization who in 2005 as the keratocystic odontogenic tumor 1, 2. Odontogenic keratocyst masquerading as a dentigerous cyst in the maxilla. Oral cavity cysts oral cavity cysts exist in jaw bones and soft tissue, gingiva odontogenic. Odontogenic tumor definition of odontogenic tumor by. There are a number of odontogenic epithelial stages and each may provide a basis for odontogenic cysts or tumors. Tumors are also called neoplasms, which means that they are composed of new and actively growing tissue. To add up the number of collected case reports, surveys were send out to. Odontogenic cysts and tumors develop during or after the formation of teeth. At the time of writing 2016, it is still the most widely used classification system although a. To compare data with various reports from other parts of the world.
Non odontogenic pain pdf non odontogenic pain pdf download. Nonodontogenic tumors of the facial bones in children and. It has sheets and strands of odontogenic epithelial cells. There were no new entities introduced and most lesions were updated, particularly as the genetic landscape of all neoplasms has evolved since 2005. Amongst all oral lesions, prevalence of odontogenic tumor is 0.
Surgery alone for oral fs results in a relatively high local recurrence rate. Although they do not normally contain odontogenic tissue, they are probably odontogenic because of their site of origin. Hematopoieticreticuloendothelial eosinophilic granuloma handschuller christian disease letterer. In two surveys of oropharyngeal tumors in cats the most frequently diagnosed tumor was scc, representing 6164% of the. Lewis key points computed tomography can be highly specific in the diagnosis of mandibular masses given an organized approach that considers both odontogenic and nonodontogenic tumors and cysts. They sometimes raise a significant diagnosis and therapeutic challenge, comparatively with previously described lesions. Several tumors exist, which only appear to occur in the jaws. Patients can present with pain of odontogenic or nonodontogenic origin, arising from the facial area, temporomandibular joints, ear, eyes, pharynx and larynx. Most pediatric tumors of the facial bones are of nonodontogenic origin 2, 3.
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